🧪 Intervention Controls
0 selected
⚙️ Global Cross-Correlation ρ̄ (Backdoor Adjustment Sensitivity)
ρ̄ =
0.30
(Low ρ̄ = less redundancy; High ρ̄ = more mechanistic overlap)
Oxford CEBM: Level I→A · II→B · III→C. Lower grades excluded from the combined HR.
📊 Overview
🔀 What-If
🔁 If-Not-For
🎯 Sensitivity
💊 Dose-Response
🕸️ Causal DAG
🧬 Scenarios
📚 Evidence
Pearl-Adjusted HR by Intervention (lower = more protective)
Sorted by raw HR
Selected Stack — Marginal Contribution to HR Reduction
Pathway-Level Combined HR
What-If Analysis: For each intervention, shows the marginal change in combined HR if that intervention were added to (or removed from) the current selection. Sorted by impact magnitude.
Waterfall: Marginal HR Contribution (Selected Protocol)
| Intervention | Current HR (all) | HR if Added/Removed | ΔNBO Prob. | Priority |
|---|
If-Not-For (Population Attributable Risk): What would the NBO probability be if a given intervention had NEVER existed (counterfactual Pearl Layer 3)?
| Intervention | PAR (abs.) | PAR% | NBO without this | Interpretation |
|---|
Sensitivity Analysis: How does the combined HR change as cross-correlation ρ̄ and baseline risk assumptions vary? Highlighted row = current ρ̄ setting.
ρ̄ Sensitivity — Combined HR for Selected Protocol
| ρ̄ | Combined HR | Abs. Risk | Rel. Reduction | NNT | Weight w |
|---|
E-Value Sensitivity — Unmeasured Confounding Threshold
| Intervention | HR | E-Value | Robustness |
|---|
Dose-response profiles for key interventions. Sliders in the left panel adjust the effective HR based on dose tier (Low / Optimal / High).
| Intervention | Dose Setting | Effective HR | Dose Description | Saturation Notes |
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🕸️ Directed Acyclic Graph — Pearl SCM Causal Structure
DAG Legend: Blue arrows = direct causal paths (do-calculus identified). Dashed lines = cross-pathway correlations (ρ). Red node = outcome (NBO). Pathway nodes are mediators. Intervention nodes connect to their respective pathway mediator.
Pre-computed optimal clinical stacks. Click a scenario to load it into the selection panel.
Evidence Summary: Raw effect sizes from systematic reviews and meta-analyses (2018–2025). SMD values pre-dating ρ̄ adjustment.
| ID | Intervention | SMD | HR (raw) | E-Value | PNS | Level | Key Citations |
|---|